Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

Chemical Constituents from Ethanoic Extracts of the Aerial Parts of Leea aequata L., a Traditional Folk Medicine of Myanmar

Nay Lin Tun 1,2,3, Dong‑Bao Hu 4 , Meng‑Yuan Xia 2, Dong‑Dong Zhang 1,2, Jun Yang 2, Thaung Naing Oo 5, Yue‑Hu Wang 2 , Xue‑Fei Yang 1,2,3

1 Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar

2 Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources,Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China

3 University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China

4 University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China

5 Forest Research Institute, Yezin, Nay Pyi Taw 05282, Myanmar

PubYear : 2019

Volume: Online artical

Publication Name: Natural Products and Bioprospecting

Page number:  1–7

Abstract:We aimed at reporting the chemical constituents and antimicrobial activities of Leea aequata L., a traditional folk medicine used in Myanmar for the treatment of wounds and skin diseases. A new neolignan, (7S,8R)-9′-O-acetylcedrusin (1), a new lactam, (3S,4S)-4-chloro-3-hydroxypiperidin-2-one (2), along with 21 known compounds, including five lignans (3–7), four flavonoid glycosides (8–11), and others (12–23), were isolated from the ethanoic extract of the aerial parts of L. aequata. The structures of the new compounds were determined by NMR, MS, and ECD spectra. For all the antimicrobial tests of the 23 compounds, only 3,4,5-trihydroxybenzoic acid ethyl ester (17) showed weak inhibitory activities against Escherichia coli and Salmonella enterica subsp. enterica.

Keywords: Leea aequata, Vitaceae, Traditional medicines, Lignans, Flavonoids

https://link.springer.com/article/10.1007%2Fs13659-019-0209-y